Progesterone increases susceptibility and decreases immune responses to genital herpes infection.

Progesterone increases susceptibility and decreases immune responses to genital herpes infection.

Depo-provera, a long-acting progestational formulation, is extensively used to facilitate an infection of sexually transmitted illnesses in animal fashions. We have beforehand reported that hormone therapies change susceptibility and immune responses to genital tract infections. In this examine we in contrast the adjustments in susceptibility of mice to genital herpes simplex virus sort 2 (HSV-2) after Depo-provera or a saline suspension of progesterone (P-sal).

We discovered that following Depo-provera-treatment, mice had extended diestrus that lasted greater than Four weeks. This coincided with a 100-fold improve in susceptibility to genital HSV-2 in contrast to that of untreated mice. Mice given P-sal have been in diestrous stage for 4 to 6 days earlier than returning to irregular reproductive cycles. When these mice have been contaminated at diestrus they confirmed a 10-fold improve in susceptibility in contrast to that of regular, untreated mice. P-sal-treated mice contaminated at estrus have been inclined to HSV-2, relying on the infectious dose.

Normal, untreated mice in estrus weren’t inclined to HSV-2, even at a excessive infectious dose of 10(7) PFU. In addition to alterations in susceptibility, Depo-provera therapy had inhibitory results on immune responses to HSV-2. Mice immunized with HSV-2 protein (gB) and handled with Depo-provera confirmed vital reducing of native HSV-2-specific immunoglobulin G (IgG) and IgA of their vaginal washes.

Mice immunized with an attenuated pressure of HSV-2 2 weeks after Depo-provera therapy failed to develop safety when challenged intravaginally with wild-type HSV-2. In distinction, mice given progesterone and immunized at diestrus or estrus have been fully shielded from intravaginal problem. These research present that Depo-provera therapy adjustments susceptibility and native immune responses to genital HSV-2 an infection. Animal fashions and vaccine methods for sexually transmitted illnesses want to contemplate the impact of hormone therapies on susceptibility and immune responses.

Progesterone increases susceptibility and decreases immune responses to genital herpes infection.
Progesterone increases susceptibility and decreases immune responses to genital herpes infection.

Interleukin-15 and pure killer and NKT cells play a essential position in innate safety towards genital herpes simplex virus sort 2 an infection.

Interleukin-15 (IL-15), pure killer (NK) cells, and NK T (NKT) cells, parts of the innate immune system, are identified to contribute to protection towards pathogens, together with viruses.

Here we report that IL-15(-/-) (NK(-) and NKT(-/+)) mice and RAG-2(-/-)/gamma(c)(-/-) (NK(-) and NKT(-)) mice that lack all lymphoid cells have been very inclined to vaginal an infection with a low dose of herpes simplex virus sort 2 (HSV-2). IL-15(-/-) and RAG-2(-/-)/gamma(c)(-/-) mice have been 100-fold extra inclined and RAG-2(-/-), CD-1(-/-) (NKT(-)), and gamma interferon (IFN-gamma)(-/-) mice have been 10-fold extra inclined to vaginal HSV-2 an infection than management C57BL/6 mice. NK and/or NKT cells have been the early supply of IFN-gamma in vaginal secretions following genital HSV-2 an infection. This examine demonstrates that IL-15 and NK-NKT cells are essential for innate safety towards genital HSV-2.

Horse IgG ELISA Kit

MBS136596-1Kit 1Kit
EUR 950

Horse IgG ELISA Kit

MBS136596-5x1Kit 5x1Kit
EUR 4365

Horse IgG ELISA Kit

MBS564133-5x96Wells 5x96Wells
EUR 2720

Horse IgG ELISA Kit

MBS564133-96Wells 96Wells
EUR 595

Horse IgG ELISA (96 Determinations)

0801221 96T
EUR 324

Horse IgG ELISA (96 Determinations)

801221 96 Determinations
EUR 324

Horse IgG ELISA Kit | E-70G

E-70G 1 x 96 well plate
EUR 712
Description:

Horse IgG ELISA Kit ; E-70G ; Immunology Consultants Laboratory

Species Reactivity: Horse

Format: Sandwich ELISA

Product Type: ELISA Kit

Range: 6.25 ng/ml - 400 mg/ml

*Horse Total IgG ELISA Kit

IHSIGGKTT each
EUR 528
Description: *Horse Total IgG ELISA Kit

Horse Leptospira IgG,Lep IgG ELISA KIT

ED0001HO 96 wells
EUR 498

Horse Leptospira IgG,Lep IgG ELISA KIT

JOT-EKD0001HO 96 wells
EUR 398.4
Description: Horse

Horse Leptospira IgG, Lep IgG ELISA Kit

MBS1610040-10x96StripWells 10x96-Strip-Wells
EUR 4470

Horse Leptospira IgG, Lep IgG ELISA Kit

MBS1610040-5x96StripWells 5x96-Strip-Wells
EUR 2270

Horse Leptospira IgG, Lep IgG ELISA Kit

MBS1610040-96StripWells 96-Strip-Wells
EUR 540

IgG ELISA Kit (Horse) (OKIA00043)

OKIA00043 96 Wells
EUR 825.6
Description: Description of target: ;Species reactivity: Horse;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 2.217 ng/ml

Horse Henipavirus IgG ELISA Kit

SL0061Ho -
EUR 528

Horse IgG

31C-CH0801 50 mg Ask for price
Description: Purified Horse IgG

Horse IgG

IHR-8160-10 10 mg
EUR 47.75

Horse IgG

IHR-8160-100 100 mg
EUR 88.2

Horse IgG

E61I024 1mg
EUR 225

Horse IgG

MBS537629-INQUIRE INQUIRE Ask for price

Horse IgG

MBS8574979-1mg 1mg
EUR 305

Horse IgG

MBS8574979-5x1mg 5x1mg
EUR 1220

Horse IgG ELISA Kit, 96 tests, Quantitative

7730 1 kit
EUR 854.4

OKIA00043-96W - IgG ELISA Kit (Horse)

OKIA00043-96W 1x96wellplate
EUR 550

Horse IgG(Immunoglobulin G) ELISA Kit

ELK1350-48T 48T Ask for price
Description: This assay employs the competitive inhibition enzyme immunoassay technique. The microtiter plate provided in this kit has been pre-coated with Horse IgG protein. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Horse IgG. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Horse IgG in the samples is then determined by comparing the OD of the samples to the standard curve.

Horse IgG(Immunoglobulin G) ELISA Kit

ELK1350-96T 96T Ask for price
Description: This assay employs the competitive inhibition enzyme immunoassay technique. The microtiter plate provided in this kit has been pre-coated with Horse IgG protein. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Horse IgG. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Horse IgG in the samples is then determined by comparing the OD of the samples to the standard curve.

Horse IgG (Immunoglobulin G) ELISA Kit

MBS7608030-10x96StripWells 10x96-Strip-Wells
EUR 3900

Horse IgG (Immunoglobulin G) ELISA Kit

MBS7608030-48StripWells 48-Strip-Wells
EUR 340

Horse IgG (Immunoglobulin G) ELISA Kit

MBS7608030-5x96StripWells 5x96-Strip-Wells
EUR 2045

Horse IgG (Immunoglobulin G) ELISA Kit

MBS7608030-96StripWells 96-Strip-Wells
EUR 455

Horse IgG (Immunoglobulin G) ELISA Kit

MBS8800352-10x96StripWells 10x96-Strip-Wells
EUR 3130

Horse IgG (Immunoglobulin G) ELISA Kit

MBS8800352-48StripWells 48-Strip-Wells
EUR 380

Horse IgG (Immunoglobulin G) ELISA Kit

MBS8800352-5x96StripWells 5x96-Strip-Wells
EUR 1710

Horse IgG (Immunoglobulin G) ELISA Kit

MBS8800352-96StripWells 96-Strip-Wells
EUR 500

Horse Immunoglobulin G (IgG) ELISA Kit

20-abx150448
  • Ask for price
  • Ask for price
  • Ask for price
  • 96 tests
  • 5 × 96 tests
  • 10 × 96 tests

Horse Immunoglobulin G (IgG) ELISA Kit

CEA544Eq-10x96wellstestplate 10x96-wells test plate
EUR 4028.46
Description: This is Competitive Enzyme-linked immunosorbent assay for detection of Horse Immunoglobulin G (IgG) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Horse Immunoglobulin G (IgG) ELISA Kit

CEA544Eq-1x48wellstestplate 1x48-wells test plate
EUR 436.93
Description: This is Competitive Enzyme-linked immunosorbent assay for detection of Horse Immunoglobulin G (IgG) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Horse Immunoglobulin G (IgG) ELISA Kit

CEA544Eq-1x96wellstestplate 1x96-wells test plate
EUR 572.76
Description: This is Competitive Enzyme-linked immunosorbent assay for detection of Horse Immunoglobulin G (IgG) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Horse Immunoglobulin G (IgG) ELISA Kit

CEA544Eq-5x96wellstestplate 5x96-wells test plate
EUR 2217.42
Description: This is Competitive Enzyme-linked immunosorbent assay for detection of Horse Immunoglobulin G (IgG) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Horse Immunoglobulin G (IgG) ELISA Kit

4-CEA544Eq
  • Ask for price
  • Ask for price
  • Ask for price
  • 1 plate of 96 wells
  • 5 plates of 96 wells
  • 10 plates of 96 wells
Description: Enzyme-linked immunosorbent assay based on the Competitive Inhibition method for detection of Horse Immunoglobulin G (IgG) in samples from Serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids. with no significant corss-reactivity with analogues from other species.

Horse Immunoglobulin G, IgG ELISA Kit

CSB-E13882Hs-24T 1 plate of 24 wells
EUR 198
Description: Quantitative competitive ELISA kit for measuring Horse Immunoglobulin G, IgG in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Horse Immunoglobulin G,IgG ELISA Kit

CSB-E13882Hs-48T 48T
EUR 192.56
Description: Equus caballus (Horse)

Horse Immunoglobulin G, IgG ELISA Kit

1-CSB-E13882Hs
  • Ask for price
  • Ask for price
  • Ask for price
  • 5 plates of 96 wells each
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
Description: Quantitative competitive ELISA kit for measuring Horse Immunoglobulin G, IgG in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Horse Immunoglobulin G,IgG ELISA Kit

CSB-E13882Hs-96T 96T
EUR 296.25
Description: Equus caballus (Horse)

Horse Immunoglobulin G (IgG) ELISA Kit

EKU04892-48T 48T
EUR 389.34

Horse Immunoglobulin G (IgG) ELISA Kit

EKU04892-5x96T 5x96T
EUR 2641.95

Horse Immunoglobulin G (IgG) ELISA Kit

EKU04892-96T 96T
EUR 556.2

Horse Immunoglobulin G,IgG ELISA Kit

EK0119 96 tests
EUR 659

Horse Immunoglobulin G (IgG) ELISA Kit

EKN46003-48T 48T
EUR 265.02

Horse Immunoglobulin G (IgG) ELISA Kit

EKN46003-5x96T 5x96T
EUR 1798.35

Horse Immunoglobulin G (IgG) ELISA Kit

EKN46003-96T 96T
EUR 378.6

Horse Immunoglobulin G,IgG ELISA Kit

EKC41073-48T 48T
EUR 328.86

Horse Immunoglobulin G,IgG ELISA Kit

EKC41073-5x96T 5x96T
EUR 2231.55

Horse Immunoglobulin G,IgG ELISA Kit

EKC41073-96T 96T
EUR 469.8

Horse Immunoglobulin G,IgG Elisa Kit

EK753041 96 Wells
EUR 0.89

Horse Immunoglobulin G,IgG ELISA KIT

JOT-EKA0004HO 96 wells
EUR 398.4
Description: Horse

Horse Immunoglobulin G,IgG ELISA KIT

EA0004HO 96 wells
EUR 498

Horse Immunoglobulin G (IgG) ELISA Kit

MBS454741-INQUIRE INQUIRE Ask for price

Horse Immunoglobulin G (IgG) ELISA Kit

MBS282597-10x96StripWells 10x96-Strip-Wells
EUR 6840

Horse Immunoglobulin G (IgG) ELISA Kit

MBS282597-48StripWells 48-Strip-Wells
EUR 480

Horse Immunoglobulin G (IgG) ELISA Kit

MBS282597-5x96StripWells 5x96-Strip-Wells
EUR 3610

Horse Immunoglobulin G (IgG) ELISA Kit

MBS282597-96StripWells 96-Strip-Wells
EUR 805

Horse Immunoglobulin G, IgG ELISA Kit

MBS1609128-10x96StripWells 10x96-Strip-Wells
EUR 4470

Horse Immunoglobulin G, IgG ELISA Kit

MBS1609128-5x96StripWells 5x96-Strip-Wells
EUR 2270

Horse Immunoglobulin G, IgG ELISA Kit

MBS1609128-96StripWells 96-Strip-Wells
EUR 540

Horse Immunoglobulin G (IgG) ELISA Kit

MBS2022125-10x96StripWells 10x96-Strip-Wells
EUR 4020

Horse Immunoglobulin G (IgG) ELISA Kit

MBS2022125-24StripWells 24-Strip-Wells
EUR 295

Horse Immunoglobulin G (IgG) ELISA Kit

MBS2022125-48StripWells 48-Strip-Wells
EUR 410

Horse Immunoglobulin G (IgG) ELISA Kit

MBS2022125-5x96StripWells 5x96-Strip-Wells
EUR 2200

Horse Immunoglobulin G (IgG) ELISA Kit

MBS2022125-96StripWells 96-Strip-Wells
EUR 545

Horse Immunoglobulin G (IgG) ELISA Kit

MBS2700206-10x96StripWells 10x96-Strip-Wells
EUR 2240

Horse Immunoglobulin G (IgG) ELISA Kit

MBS2700206-24StripWells 24-Strip-Wells
EUR 220

Horse Immunoglobulin G (IgG) ELISA Kit

MBS2700206-48StripWells 48-Strip-Wells
EUR 280

Horse Immunoglobulin G (IgG) ELISA Kit

MBS2700206-5x96StripWells 5x96-Strip-Wells
EUR 1175

Horse Immunoglobulin G (IgG) ELISA Kit

MBS2700206-96StripWells 96-Strip-Wells
EUR 330

Horse Immunoglobulin G, IgG ELISA Kit

MBS700370-10x96StripWells 10x96-Strip-Wells
EUR 4010

Horse Immunoglobulin G, IgG ELISA Kit

MBS700370-24StripWellsLIMIT1 24-Strip-Wells(LIMIT1)
EUR 275

Horse Immunoglobulin G, IgG ELISA Kit

MBS700370-48StripWells 48-Strip-Wells
EUR 355

Horse Immunoglobulin G, IgG ELISA Kit

MBS700370-5x96StripWells 5x96-Strip-Wells
EUR 2095

Horse Immunoglobulin G, IgG ELISA Kit

MBS700370-96StripWells 96-Strip-Wells
EUR 490

Horse Immunoglobulin G, IgG ELISA Kit

MBS9424467-5x96Tests 5x96Tests
EUR 3065

Horse Immunoglobulin G, IgG ELISA Kit

MBS9424467-96Tests 96Tests
EUR 670

Horse Immunoglobulin G -IgG- ELISA Kit

QY-E120063 96T
EUR 580

Horse Immunoglobulin G(IgG)ELISA Kit

YLA0014HO-48T 48T Ask for price

Horse Immunoglobulin G(IgG)ELISA Kit

YLA0014HO-96T 96T Ask for price

Horse BSA Antibody IgG (BSA-IgG) ELISA Kit

MBS9932175-10x96StripWells 10x96-Strip-Wells
EUR 6725

Horse BSA Antibody IgG (BSA-IgG) ELISA Kit

MBS9932175-48StripWells 48-Strip-Wells
EUR 550

Horse BSA Antibody IgG (BSA-IgG) ELISA Kit

MBS9932175-5x96StripWells 5x96-Strip-Wells
EUR 3420

Horse BSA Antibody IgG (BSA-IgG) ELISA Kit

MBS9932175-96StripWells 96-Strip-Wells
EUR 765

Horse Platelet Antibodies IgG ELISA Kit

MBS033062-10x96StripWells 10x96-Strip-Wells
EUR 6725

Horse Platelet Antibodies IgG ELISA Kit

MBS033062-48StripWells 48-Strip-Wells
EUR 550

Horse Platelet Antibodies IgG ELISA Kit

MBS033062-5x96StripWells 5x96-Strip-Wells
EUR 3420

Horse Platelet Antibodies IgG ELISA Kit

MBS033062-96StripWells 96-Strip-Wells
EUR 765

Horse Nucleosome Antibody IgG ELISA Kit

MBS013729-10x96StripWells 10x96-Strip-Wells
EUR 6725

Horse Nucleosome Antibody IgG ELISA Kit

MBS013729-48StripWells 48-Strip-Wells
EUR 550

Horse Nucleosome Antibody IgG ELISA Kit

MBS013729-5x96StripWells 5x96-Strip-Wells
EUR 3420

Horse Nucleosome Antibody IgG ELISA Kit

MBS013729-96StripWells 96-Strip-Wells
EUR 765

Horse Lactoferrin Antibody IgG ELISA Kit

MBS016972-10x96StripWells 10x96-Strip-Wells
EUR 6725

Horse Lactoferrin Antibody IgG ELISA Kit

MBS016972-48StripWells 48-Strip-Wells
EUR 550

Horse Lactoferrin Antibody IgG ELISA Kit

MBS016972-5x96StripWells 5x96-Strip-Wells
EUR 3420

Horse Lactoferrin Antibody IgG ELISA Kit

MBS016972-96StripWells 96-Strip-Wells
EUR 765

Horse FcGRI Antibody IgG (FcGRI-IgG) ELISA Kit

MBS9372261-10x96StripWells 10x96-Strip-Wells
EUR 6725

Horse FcGRI Antibody IgG (FcGRI-IgG) ELISA Kit

MBS9372261-48StripWells 48-Strip-Wells
EUR 550

Horse FcGRI Antibody IgG (FcGRI-IgG) ELISA Kit

MBS9372261-5x96StripWells 5x96-Strip-Wells
EUR 3420

Horse FcGRI Antibody IgG (FcGRI-IgG) ELISA Kit

MBS9372261-96StripWells 96-Strip-Wells
EUR 765

Horse Infectious Mononucleosis IgG ELISA Kit

MBS044957-10x96StripWells 10x96-Strip-Wells
EUR 6725

Horse Infectious Mononucleosis IgG ELISA Kit

MBS044957-48StripWells 48-Strip-Wells
EUR 550

Horse Infectious Mononucleosis IgG ELISA Kit

MBS044957-5x96StripWells 5x96-Strip-Wells
EUR 3420

Horse Infectious Mononucleosis IgG ELISA Kit

MBS044957-96StripWells 96-Strip-Wells
EUR 765

Horse Cochlin Antibody IgG (COCH-IgG) ELISA Kit

MBS9361402-10x96StripWells 10x96-Strip-Wells
EUR 6725

Horse Cochlin Antibody IgG (COCH-IgG) ELISA Kit

MBS9361402-48StripWells 48-Strip-Wells
EUR 550

Horse Cochlin Antibody IgG (COCH-IgG) ELISA Kit

MBS9361402-5x96StripWells 5x96-Strip-Wells
EUR 3420

Horse Cochlin Antibody IgG (COCH-IgG) ELISA Kit

MBS9361402-96StripWells 96-Strip-Wells
EUR 765

Horse Toxoplasma gondii IgG(Toxo-IgG) Elisa Kit

EK753016 96 Wells
EUR 0.88

Horse Endomysial Antibody IgG (EM-IgG) ELISA Kit

MBS9362044-10x96StripWells 10x96-Strip-Wells
EUR 6725

Horse Endomysial Antibody IgG (EM-IgG) ELISA Kit

MBS9362044-48StripWells 48-Strip-Wells
EUR 550

Horse Endomysial Antibody IgG (EM-IgG) ELISA Kit

MBS9362044-5x96StripWells 5x96-Strip-Wells
EUR 3420

Horse Endomysial Antibody IgG (EM-IgG) ELISA Kit

MBS9362044-96StripWells 96-Strip-Wells
EUR 765

Horse Sulfatide Antibody IgG (SFT-IgG) ELISA Kit

MBS9901560-10x96StripWells 10x96-Strip-Wells
EUR 6725

Horse Sulfatide Antibody IgG (SFT-IgG) ELISA Kit

MBS9901560-48StripWells 48-Strip-Wells
EUR 550

Horse Sulfatide Antibody IgG (SFT-IgG) ELISA Kit

MBS9901560-5x96StripWells 5x96-Strip-Wells
EUR 3420

Horse Sulfatide Antibody IgG (SFT-IgG) ELISA Kit

MBS9901560-96StripWells 96-Strip-Wells
EUR 765

Horse Toxoplasma gondii IgG(Toxo-IgG) ELISA Kit

SL0017Ho -
EUR 528

Horse Leptospira antibody IgG(LEP-IgG) ELISA Kit

SL0020Ho -
EUR 528

Almost all individuals with initially symptomatic HSV-2 an infection have symptomatic recurrences. More than 35% of such sufferers have frequent recurrences. Recurrence charges are particularly excessive in individuals with an prolonged first episode of an infection, no matter whether or not they obtain antiviral chemotherapy with acyclovir. Men with genital HSV-2 an infection have about 20% extra recurrences than do girls, an element which will contribute to the upper price of HSV-2 transmission from males to girls than from girls to males and to the persevering with epidemic of genital herpes within the United States.

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